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我们以往的工作曾看到:损毁大鼠蓝斑核(LC)可加强针刺镇痛作用;电针又可压抑蓝斑核神经元的自发放电活动,这说明LC在针刺镇痛中起着一定的作用。近年来国内外大量工作已证明脑内的内源性吗啡样物质与针刺镇痛效应有关。Atweh、Pert、Korf等人认为LC内存在有高浓度的吗啡受体,并认为LC是对吗啡感受性较高的部位。LC虽然是儿茶酚胺能(主要是去甲肾上腺素能)胞体的集中部位,但也有多种其它神经递质存在,因此其功能是较为复杂的。为了进一步探讨针刺镇痛与LC内的内源性吗啡样物质的关系,我们观察了在电针对LC神经元自发放电的影响中,吗啡的特异对抗剂——纳洛酮
Our previous work has seen that damage to the locus coeruleus (LC) in rats can enhance the analgesic effects of acupuncture; electroacupuncture can restrain the spontaneous firing activity of locus coeruleus neurons, indicating that LC plays a role in acupuncture analgesia With a certain role. In recent years, a great deal of work at home and abroad has proved that the endogenous morphine-like substance in the brain is related to the analgesic effect of acupuncture. Atweh, Pert, Korf and others believe there is a high concentration of morphine receptors in LC, and LC is considered to be more sensitive to morphine. Although LCs are concentrated in catecholaminergic (mainly noradrenergic) cell bodies, many other neurotransmitters are also present and their function is therefore more complex. In order to further investigate the relationship between acupuncture analgesia and endogenous morphine-like substances in LC, we observed the effects of electro-acupuncture on spontaneous discharge of LC neurons, the morphine-specific antagonist naloxone