论文部分内容阅读
panipenem/betamipron是碳青霉烯类抗生素panipenem(PAPM)和有机阴离子运输抑制剂betamipron(BP)等量混合的复合剂.对金葡菌、肠球菌等革兰阳性菌,大肠杆菌、绿脓杆菌等革兰阴性菌,拟杆菌等厌氧菌具有抗菌活性.对用各种菌引起的小鼠实验性腹腔感染性疾病有治疗效果.用本品0.5g在1h滴注完毕时的血浆浓度,PAPM为27.5μg/ml,BP为15.6μg/ml,血中半衰期分别为约70和约40min.24h尿中排泄率,PAPM为28.5%,BP为94.7%.如包括代谢物在内,PAPM的排泄率为77.5%.按疾病分类的临床有效率,成人呼吸道感染为83.4%,尿道感染为 81.4%,妇产科感染为95.1%,合计总有效率为82.0%(1435/
Panipenem / betamipron is a mixture of carbapenem antibiotic panipenem (PAPM) and organic anion transport inhibitor betamipron (BP) in the same amount, which is effective against Gram-positive bacteria such as Staphylococcus aureus and enterococci, Escherichia coli, Pseudomonas aeruginosa Such as Gram-negative bacteria, Bacteroides and other anaerobic bacteria have antibacterial activity on mice caused by a variety of experimental experimental intraperitoneal infectious diseases have a therapeutic effect with this product 0.5g in 1h infusion of plasma concentration, PAPM was 27.5 μg / ml, BP was 15.6 μg / ml and blood half-lives were about 70 and about 40 min, respectively, for 24 h urinary excretion rates, PAPM was 28.5% and BP was 94.7%. As with metabolites, excretion of PAPM According to the clinically effective rate of disease classification, the rate of adult respiratory infection was 83.4%, urinary tract infection was 81.4%, obstetrics and gynecology infection was 95.1%, the total effective rate was 82.0% (1435 /