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我们在31例预防性应用ATG(抗人T淋巴细胞球蛋白)的肾脏移植病人中,用流式细胞分析的方法动态地监测外周血CD3阳性细胞水平.以CD3阳性细胞水平5%为临介组比较病人的肾功能恢复时间、急性排斥反应率、机会性感染率和骨髓抑制发生率.结果发现,CD3阳性细胞<5%组在机会性感染率和骨髓抑制发生率上明显高于CD3阳性细胞>5%组.由此我们认为,ATG应用期间监测T淋巴细胞亚群十分必要,治疗期间CD3阳性水平应保持在5%以上,一旦CD3阳性细胞水平下降到5%以下,应减少ATG用量或缩短疗程.
We performed a dynamic flow cytometric analysis of peripheral blood CD3-positive cells in 31 patients with renal transplant recipients who were prophylactic with ATG (anti-human T-lymphocyte globulin). Pro-mediated by 5% CD3-positive cells The patients were compared with the recovery time of renal function, the rate of acute rejection, the opportunistic infection rate and the incidence of myelosuppression.The results showed that the incidence of opportunistic infection and myelosuppression in CD3 positive cells <5% group was significantly higher than that of CD3 positive Thus, we believe it is necessary to monitor the T-lymphocyte subsets during ATG application and maintain CD3 positive levels above 5% during treatment and reduce the amount of ATG once the level of CD3-positive cells falls below 5% Or shorten the course of treatment.