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目的 观察VitD3 及微量元素硒对佝偻病的治疗作用。方法 把佝偻病患儿分为非药物治疗的对照组(Ⅰ )、VitD3 治疗组 (Ⅱ )和VitD3+硒治疗组 (Ⅲ ) ,分别测定治疗前后血硒、钙、磷、镁水平 ,免疫球蛋白IgG、IgA、IgM水平 ,同时做T淋巴细胞转化试验。 结果 Ⅱ、Ⅲ组治疗后的血硒、钙、磷、镁水平及免疫功能较Ⅰ组有所提高 ,并以Ⅲ组为最明显。Ⅱ、Ⅲ组治疗前后的各指标经t检验有显著性差异 (P <0 0 1)。结论 VitD3 和微量元素硒对佝偻病都有较好的治疗作用 ,两药联合使用时效果更好。VitD3 和硒可能存在协同功能。
Objective To observe the therapeutic effect of VitD3 and trace element selenium on rickets. Methods The children with rickets were divided into non-drug control group (Ⅰ), VitD3 treatment group (Ⅱ) and VitD3 + selenium treatment group (Ⅲ). The levels of selenium, calcium, phosphorus and magnesium in serum before and after treatment were measured, , IgA, IgM levels, while doing T lymphocyte transformation test. Results The levels of selenium, calcium, phosphorus, magnesium and immune function in group Ⅱ and Ⅲ after treatment were higher than those in group Ⅰ, and were most obvious in group Ⅲ. The indexes before and after treatment in group Ⅱ and Ⅲ were significantly different by t test (P <0.01). Conclusion VitD3 and trace element selenium have a good therapeutic effect on rickets, the two drugs combined effect is better. There may be synergy between VitD3 and selenium.