CTL和NK之间的关系虽经多年研究但仍有争议。问题在于只根据功能去鉴别这两种细胞。所有不受MHC限制的细胞毒性淋巴细胞都被认为是NK细胞,而具有抗原特异性的细胞则被认为是CTL。但人们观察到在植物血凝素、同种抗原和淋巴因子活化的淋巴细胞中存在表达T细胞抗原的非MHC限制性细胞毒细胞。这就使得上述差别更 The relationship between CTL and NK is controversial despite years of research. The problem is that the two cells are identified only by function. All cytotoxic lymphocytes that are not restricted by MHC are considered NK cells, whereas cells with antigen specificity are considered CTLs. However, it has been observed that there are non-MHC-restricted cytotoxic cells that express T cell antigens in phytohemagglutinin, alloantigen and lymphokine activated lymphocytes. This makes the difference more