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肿瘤转移是肿瘤致死的重要原因,临床发现,肿瘤最初的生长主要通过诱导血管新生(angiogenesis)来提供所需的营养,但是肿瘤转移的主要途径并不是通过新生血管,而是通过肿瘤诱导的新生淋巴管进行转移。淋巴管新生(lymphangiogenesis)是在原来淋巴管的基础上长出新的毛细淋巴管的过程,毛细淋巴管仅由一层内皮细胞组成,几乎不被周细胞或平滑肌细胞包被,它是肿瘤细胞转移和扩散的重要途径。因此,肿瘤细胞通过新生淋巴管转移至淋巴结可被视为肿瘤转移的预后指标,抑制肿瘤的淋巴管新生被认为是肿瘤诊断和决定医治的重要治疗方法。但是由于缺乏淋巴特异性标记和对淋巴管新生知识的匮乏,淋巴管新生并没有像血管新生那样得到关注。近年来,淋巴管新生信号途径的阐明,淋巴内皮细胞(lymphatic endothelial cell,LEC)分子标记物如Prox-1、LYVE-1和podoplanin等的发现和淋巴内皮细胞的成功分离和培养,使得淋巴管新生方面的研究更深入。
Tumor metastasis is an important cause of tumor death. Clinically, the initial growth of tumor mainly provides the needed nutrition by inducing angiogenesis, but the main path of tumor metastasis is not through neovascularization, but through tumor-induced newborn Lymphatic vessels for transfer. Lymphangiogenesis is the process of growing new lymphatic capillaries based on the original lymphatic vessels. The lymphatic vessels consist of only one layer of endothelial cells, and are rarely surrounded by pericytes or smooth muscle cells. They are tumor cells An important way to transfer and spread. Therefore, the transfer of tumor cells to the lymph nodes via nascent lymphatic vessels can be considered as a prognostic indicator of tumor metastasis. Inhibiting lymphangiogenesis in the tumor is considered as an important treatment for tumor diagnosis and treatment decision. However, due to lack of lymphoid-specific markers and lack of knowledge of lymphangiogenesis, lymphangiogenesis does not receive as much attention as angiogenesis. In recent years, the elucidation of the signal pathway of lymphangiogenesis, the discovery of lymphatic endothelial cell (LEC) molecular markers such as Prox-1, LYVE-1 and podoplanin, and the successful isolation and culture of lymphatic endothelial cells, Freshman research is more in-depth.