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检测了３６例临床诊断为颞下颌关节紊乱综合征（ＴＭＪＤＳ）各期（功能紊乱期、结构紊乱期、器质性改变期）患者关节滑液中白介素－６（ＩＬ－６）的活性。结果表明：ＩＬ－６活性与ＴＭＪＤＳ病变程度有关，随病情加重，ＩＬ－６活性增高。ＩＬ－６水平在一定程度上反映了关节内自身免疫反应的强弱。ＴＭＪＤＳ患者关节内在在的骨关节病（ＯＡ）病变使软骨中的封闭抗原暴露，诱发自身免疫反应并刺激产生了ＩＬ－６，升高的ＩＬ－６活性反过来通过增强自身免疫反应来加重ＴＭＪＯＡ病变，如此形成恶性循环。对ＩＬ－６的研究，有助于解决ＴＭＪＯＡ病程迁延、久治不愈的问题，从而使临床治疗更为有效。
The activity of interleukin-6 (IL-6) in synovial fluid of 36 patients diagnosed as TMJ stage (dysfunction stage, structural disorder and organic change stage) was detected. The results showed that the activity of IL-6 was related to the degree of TMJDS lesion. With the aggravation of disease, the activity of IL-6 increased. The level of IL-6 to some extent reflects the strength of the autoimmune reaction within the joint. TMJDS patients with intra-articular osteoarthropathy (OA) lesions expose blocked antigen in cartilage, induce an autoimmune response and stimulate the production of IL-6, and elevated IL-6 activity in turn increases TMJOA by enhancing the autoimmune response Lesions, so a vicious circle. The study of IL-6 will help to solve the problem of long-lasting TMJOA course of disease and prolonged healing, thus making clinical treatment more effective.