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阿片依赖已成为当今世界严重的社会问题和医学问题。研究阿片依赖的机制及其治疗对策，不仅是社会的当务之急，也是神经生物学研究的重要课题。阿片依赖的主要特点是强迫性寻求用药［１］，它贯穿整个依赖过程，其他特点是戒断综合征、复发性和耐受性。阿片类药物中海洛因的滥
Opioid dependence has become a serious social and medical problem in the world today. To study the mechanism of opioid dependence and its treatment is not only a top priority of the society, but also an important issue in neurobiology research. The main feature of opioid dependence is the forced seeking of medication [1], which runs through the entire reliance process and is characterized by withdrawal syndrome, relapse and tolerance. Heroin abuse in opioids