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恶性肿瘤的发病人数逐年增多,已成为危害人们健康的一大杀手。传统的抗肿瘤治疗包括手术、化疗、放疗。而免疫治疗因在抗肿瘤的过程中毒副作用小、耐受性好而逐渐为人们所重视。树突状细胞(dendritic cell,DC)在免疫治疗抗肿瘤中占有重要的地位。DC联合化疗抗肿瘤是很有前景的组合。一、DC的生物学特性DC是特异性抗原提呈细胞,在诱导和调节免疫方面起着重要作用[1]。DC是免疫反应的发起者,少量DC负载低水平的抗原即可激活静止的初始B记忆细胞、T淋巴细胞。负载肿瘤相
The number of malignant tumors increased year by year, has become a major killer of people’s health. Traditional anti-cancer treatment including surgery, chemotherapy, radiotherapy. The immunotherapy because of the anti-tumor process in the side effects of small, well tolerated and gradually as people pay attention. Dendritic cells (DCs) play an important role in the immunotherapy of anti-tumor. DC combination chemotherapy anti-tumor is a very promising combination. First, the biological characteristics of DC DC is a specific antigen-presenting cells, plays an important role in the induction and regulation of immunity [1]. DCs are the initiators of immune responses. Small amounts of DC-loaded antigens can activate resting primary B memory cells, T lymphocytes. Load tumor phase