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以前,外用药剂主要用以产生局部作用,如消炎镇痛药(水杨酸类、甾体类和非甾体类)等的外用制剂。近年来出现了产生全身作用的透皮治疗系统——TTS(transdermaltherapeutic system),如抗晕动病药(东茛菪碱贴膏)、循环系统药(硝酸甘油、消心痛、心得安、氯压定等),此外还有苯丙胺等。利用TTS制成的硝酸甘油(GNT)贴膏剂有transderm-Nitro(TTS-NTG)、Nitro-Dur和Nitrodisc(MDD-NG)等。本文讨论硝酸甘油和消心痛的贴膏剂。一、贴膏剂的组成材料 1.硝酸甘油贴膏剂
Previously, topical agents were mainly used to produce topical effects such as anti-inflammatory analgesics (salicylates, steroids and non-steroidal) topical preparations. In recent years there has been a transdermal therapeutic system that produces a systemic effect, such as anti-motion sickness medicine (scopolamine plaster), circulatory system medicine (nitroglycerin, ambroxol, propranolol, Etc.), in addition to amphetamine and so on. Nitroglycerin (GNT) patches made with TTS are transderm-Nitro (TTS-NTG), Nitro-Dur and Nitrodisc (MDD-NG) and others. This article discusses nitroglycerin and painkillers. First, the composition of the material paste 1. Nitroglycerin paste