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目的研究ＴＧＦ┐βＲⅡ表达与胃癌的发生、生物学行为和预后的关系。方法应用免疫组织化学Ｓ┐Ｐ方法检测２０例正常胃粘膜、１０例肠化生，２１例异型增生及１１０例胃癌手术标本中ＴＧＦ┐βＲⅡ的表达情况。结果正常胃粘膜及肠化生ＴＧＦ┐βＲⅡ表达均阳性、异型增生表达阳性率为９５．２４％，胃癌表达阳性率为２３．６４％，其中无区域淋巴结转移者阳性率为４２．８６％，有区域淋巴结转移者阳性率为１７．０７％（Ｐ＜０．０１），ＴＧＦ┐βＲⅡ表达水平与胃癌ＰＣＮＡ表达、胃癌浸润胃壁深度和ｐＴＮＭ分期呈负相关（Ｐ＜０．０１）。ＴＧＦ┐βＲⅡ阳性者术后三年、五年生存率分别为７３．３０％、５４．５２％。而阴性者为４８．６０％、２４．８０％，两组差别均有显著性意义（Ｐ＜０．０１）。结论胃癌由于ＴＧＦ┐βＲⅡ减少而逃逸ＴＧＦ┐β的抑制作用，加速恶性细胞的增殖、浸润和转移。故检测胃粘膜活检及癌组织中ＴＧＦ┐βＲⅡ表达状况，有助于进一步了解胃粘膜癌变倾向及胃癌生物学行为和对患者预后的判断。
Objective To investigate the relationship between the expression of TGF┐βRII and the occurrence, biological behavior and prognosis of gastric cancer. Methods The expression of TGF-βRII in 20 cases of normal gastric mucosa, 10 cases of intestinal metaplasia, 21 cases of dysplasia and 110 cases of gastric cancer was detected by immunohistochemistry. Results The positive rate of positive expression of TGF┐βRII and dysplasia in normal gastric mucosa and intestinal metaplasia was 95.24%. The positive rate of gastric cancer was 23.64%. The positive rate of no regional lymph node metastasis was 42.86%. The positive rate of patients with regional lymph node metastasis was 17.07% (P<0.01). The expression of TGF┐βRII was negatively correlated with the expression of PCNA in gastric cancer, the depth of gastric cancer infiltrating the stomach wall and the pTNM stage (P<0.01). The three-year and five-year survival rates of TGF-βRII-positive patients were 73.30% and 54.52%, respectively. The negative cases were 48.60% and 24.80%. There was significant difference between the two groups (P<0.01). Conclusion The inhibition of TGF-βRII by TGF-βRII in gastric cancer evades the inhibitory effect of TGF-β and accelerates the proliferation, invasion and metastasis of malignant cells. Therefore, the detection of gastric mucosal biopsy and the expression of TGF-βRII in cancer tissues can help to further understand the tendency of gastric cancer and the biological behavior of gastric cancer and the judgment of the prognosis of patients.