1,3,4-噁二唑类化合物因其独特的生物活性在医药、农药等领域受到广泛关注。将不同的杂环引入到1,3,4-噁二唑环中,能生成一系列具有广谱医药活性的化合物,在新型医药合成中发挥越来越重要的作用。按照不同的杂环进行分类,从抑制活性方面对1,3,4-噁二唑类化合物的医药活性研究进展进行了综述。 1,3,4-oxadiazole compounds have attracted wide attention in the fields of medicine and pesticide for their unique biological activity. The introduction of different heterocycles into the 1,3,4-oxadiazole ring can generate a series of compounds with broad spectrum of pharmaceutical activities, playing an increasingly important role in the synthesis of novel pharmaceuticals. According to the classification of different heterocycles, the research progress on the pharmaceutical activity of 1,3,4-oxadiazoles was reviewed from the aspects of inhibitory activity.