早期生长反应基因 Egr- 1属即刻早期基因家族 ,其编码的蛋白产物是一种含锌指结构的转录因子 ,能与多种下游基因的启动子区域相结合 ,上调或下调基因的转录 ,产生各种生物学功能。Egr- 1不仅与细胞生长有关 ,而且参与多种细胞的正常分化。近年来国外的一些研究表明 ,Egr- 1在多种肿瘤细胞中表达消失 ,外源性 Egr- 1的导入有抑制肿瘤细胞生长的作用 The early growth response gene Egr-1 is an immediate early gene family. The encoded protein product is a zinc finger structure transcription factor that can bind to the promoter regions of a variety of downstream genes and up-regulate or down-regulate gene transcription. Various biological functions. Egr-1 is involved not only in cell growth but also in the normal differentiation of many cells. In recent years, some foreign studies have shown that the expression of Egr-1 disappears in many kinds of tumor cells, and the introduction of exogenous Egr-1 can inhibit the growth of tumor cells.