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目的探讨2型糖尿病人群肝功能异常的影响因素,为其预防控制措施提供理论依据。方法于2014年对淮安市清河区和淮安区在社区管理的2型糖尿病人群开展问卷调查、体格测量和生化检验。用SPSS 19.0对研究因素进行单因素及多因素logistic回归分析。结果本次调查共纳入2型糖尿病患者9 773例,发现肝功能异常2 385例,异常率为24.4%。单因素logistic回归分析得出性别、年龄、居住地、吸烟、饮酒、饮茶、口服降糖药、控制饮食、加强运动、高血压、高血脂、冠心病和脑卒中13个有统计学意义的影响因素,多因素logistic回归结果显示,性别(OR=1.924,95%CI:1.706~2.170)、年龄(OR=2.107,95%CI:1.774~2.503)、居住地(OR=1.592,95%CI:1.417~1.788)、饮酒(OR=1.252,95%CI:1.098~1.427)、高血压(OR=1.393,95%CI:1.257~1.544)、高血脂(OR=1.235,95%CI:1.095~1.392)和脑卒中(OR=1.172,95%CI:1.017~1.356)是2型糖尿病人群肝功能异常的危险因素,而饮茶(OR=0.829,95%CI:0.724~0.950)、口服降糖药(OR=0.868,95%CI:0.783~0.963)是保护因素。结论 2型糖尿病人群肝功能异常率较高,受到多危险因素共同影响,建议针对危险因素采取有效的干预控制措施以减少2型糖尿病人群肝功能异常的发生。
Objective To investigate the influencing factors of abnormal liver function in type 2 diabetes mellitus and to provide theoretical basis for their prevention and control measures. Methods In 2014, questionnaires, physical measurements and biochemical tests were conducted on community-managed type 2 diabetic patients in Qinghe District and Huaian District of Huaian City. Univariate and multivariate logistic regression analyzes of the study factors were performed using SPSS 19.0. Results A total of 9 773 patients with type 2 diabetes mellitus were included in this survey. There were 2 385 cases of abnormal liver function with an abnormal rate of 24.4%. Univariate logistic regression analysis showed that there were 13 statistically significant differences in sex, age, place of residence, smoking, drinking, drinking tea, oral hypoglycemic agents, diet control, strengthening exercise, hypertension, hyperlipidemia, coronary heart disease and stroke Multivariate logistic regression analysis showed that gender (OR = 1.924, 95% CI: 1.706-2.170), age (OR = 2.107, 95% CI: 1.774-2.503), place of residence (OR = 1.592, 95% CI (OR = 1.252, 95% CI: 1.098-1.427), high blood pressure (OR = 1.393, 95% CI: 1.257-1.544) 1.392) and stroke (OR = 1.172, 95% CI: 1.017-1.356) were risk factors for abnormal liver function in type 2 diabetic patients, while drinking tea (OR = 0.829, 95% CI 0.724-0.950) Drugs (OR = 0.868, 95% CI: 0.783-0.963) are protective factors. Conclusions The abnormal rate of liver function in type 2 diabetic patients is high and affected by many risk factors. It is suggested that effective intervention measures should be taken to reduce the incidence of abnormal liver function in type 2 diabetic patients.