论文部分内容阅读
目的探讨艾滋病患者真菌感染的发病率、临床表现特点及预后等。方法回顾性观察了福州市传染病院近20年来收治的艾滋病患者中真菌感染的情况,并对真菌感染者予以抗真菌治疗。结果430例艾滋病患者中并发真菌感染者213例(占49.5%),医院感染55例(占25.8%),院外感染158例(占74.2%)。其中多部位感染者105例(占49.3%)。易感因素为并发结核、慢性肝炎、免疫力缺陷(CD450个/μl),或长期应用抗结核药和抗菌素,以及未及时抗病毒治疗者。结论艾滋病患者并发真菌感染并不少见,医院外感染占多数,真菌性败血症合并肺部真菌感染预后差。关键在于及时发现与治疗,更重要在于预防。
Objective To investigate the incidence of fungal infection in AIDS patients, clinical features and prognosis. Methods Retrospectively observed the fungal infections in AIDS patients admitted to Fuzhou Infectious Diseases Hospital for nearly 20 years and treated them with antifungal therapy. Results Among 430 AIDS patients, 213 cases (49.5%) had fungal infection, 55 (25.8%) had nosocomial infection and 158 (74.2%) had nosocomial infection. 105 were infected in multiple sites (49.3%). Susceptibility to concurrent tuberculosis, chronic hepatitis, immune deficiency (CD450 / μl), or long-term use of anti-TB drugs and antibiotics, as well as those who did not receive timely antiviral therapy. Conclusions It is not uncommon for AIDS patients to suffer from fungal infection. Most of them are outside the hospital. Fungal sepsis is associated with poor prognosis of pulmonary fungal infection. The key lies in the timely detection and treatment, more importantly, prevention.