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目的:调查妊娠期妇女下生殖道感染及不良妊娠结局的发生率。方法:对象为在天坛医院进行产前检查并住院分娩的412例孕妇,孕36周时取阴道及宫颈分泌物进行滴虫(T)、外阴阴道假丝酵母菌病(VVC)、细菌性阴道病(BV)、衣原体(CT)、支原体(UU或Mh)及B族-溶血性链球菌(GBS)检测。根据感染情况分为感染组和非感染组,并追踪两组患者不良妊娠结局的发生情况。结果:412例妊娠期妇女下生殖道感染总检出率为27.62%,单一病原菌感染者70例,检出率为16.99%,其中UU最多,检出率6.55%,BV次之,检出率2.91%。多种病原菌同时感染者44例,检出率10.68%,其中以BV合并其他病原菌感染者最多,检出率7.28%。感染组胎膜早破、未足月胎膜早破、早产、产褥感染、绒毛膜羊膜炎发生率均较非感染组高(与非感染组相比,P<0.05)。BV合并其它病原菌感染导致不良妊娠结局的总致病率为96.64%,远高于其它单一病原菌感染的致病率。结论:UU或BV合并其它病原微生物感染是妊娠期下生殖道感染中较常见的感染类型,相对于其它单一病原体感染,BV合并其它病原菌感染更易导致不良妊娠结局的发生,有必要对妊娠期妇女进行下生殖道感染的筛查和治疗。
Objective: To investigate the incidence of genital tract infections and adverse pregnancy outcomes in pregnant women. Methods: Forty-one pregnant women with antenatal examination and hospital delivery at Tiantan Hospital were treated with vaginal and cervical secretions for trichomoniasis (T), vulvovaginal candidiasis (VVC), bacterial vaginosis (BV), Chlamydia (CT), Mycoplasma (UU or Mh) and B-hemolytic Streptococcus (GBS). According to the infection, the patients were divided into infected group and non-infected group, and the incidence of adverse pregnancy outcome was tracked in both groups. Results: The total detection rate of genital tract infection in 412 pregnant women was 27.62%, 70 cases of single pathogen infection were detected, the detection rate was 16.99%, of which UU was the most, the detection rate was 6.55%, BV was the second, the detection rate 2.91%. 44 cases of multiple pathogens simultaneously infected with the detection rate of 10.68%, of which BV combined with other pathogens most infected, the detection rate of 7.28%. The incidence of premature rupture of membranes, premature rupture of membranes, premature delivery, puerperal infection and chorioamnionitis in infection group were higher than those in non-infected group (P <0.05). BV combined with other pathogen infections lead to a total prevalence of adverse pregnancy outcomes was 96.64%, much higher than the incidence of other single pathogenic infection. Conclusions: UU or BV combined with other pathogenic microorganisms is the most common type of infection in lower genital tract infection during pregnancy. Compared with other single pathogen infections, BV combined with other pathogen infections can lead to adverse pregnancy outcomes. The lower genital tract infection screening and treatment.