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本文旨在探讨抗痫液对抗癫痫作用的机理,以角膜电刺激诱发小鼠精神运动性癫痫发作为模型,观察其对小鼠精神运动性发作及谷氨酸钠惊厥作用对抗作用及对脑内游离r-氨基丁酸(GABA)含量的影响。结果显示抗痫液能明显对抗小鼠精神运动性发作,并可抑制脑内游离GA-BA含量的降低(P<0.01),使之趋于正常水平;同时,该药还可对抗谷氨酸钠诱发的小鼠癫痫发作(P<0.01)。从而,为抗痫液的临床应用进一步提供了实验依据,并且提示该药的作用机制可能与其影响脑内 GABA的降解或合成,调节谷氨酸与GABA的平衡有关。
This article aims to explore the antiepileptic mechanism of anti-epileptic fluid. The model is used to evaluate the effects of anti-epileptic fluid on epilepsy induced by corneal electrical stimulation. The effects of anti-epileptic effects on psychiatric exercise seizures and sodium glutamate seizures in mice are observed. Effect of free r-aminobutyric acid (GABA) content. The results showed that the anti-epileptic fluid can significantly counteract the psychomotor seizures in mice and inhibit the decrease of free GA-BA content in the brain (P<0.01), making it normal; meanwhile, the anti-seizure fluid can also fight glutamate. Sodium-induced seizures in mice (P < 0.01). Thus, the experimental basis for the clinical application of anti-epileptic fluid is further provided, and it is suggested that the mechanism of action of the drug may be related to its influence on the degradation or synthesis of GABA in the brain and the regulation of the balance between glutamic acid and GABA.