膜性肾病(membranous nephropathy,MN)是一种自身免疫性疾病,其发病主要是由于自身抗体识别肾小球足细胞靶抗原,在足突下和上皮下沉积电子致密物,激活补体形成膜攻击复合物从而引起足细胞损伤并引发蛋白尿和低蛋白血症等临床症状。按照其发病原因分为特发性MN(idiopathic MN,IMN)和继发性MN(secondary MN,SMN),其中IMN约占所有MN的70%。目前文献报道MN发病机制与 Membranous nephropathy (MN) is an autoimmune disease whose pathogenesis is mainly due to autoantibodies recognizing glomerular podocyte target antigens, deposition of electron-dense substances under and in the foot process, activation of complement formation membrane attack The complex thus causes podocyte damage and triggers clinical symptoms such as proteinuria and hypoalbuminemia. According to their causes, they were divided into idiopathic MN (IMN) and secondary MN (SMN). IMN accounted for 70% of all MNs. The current literature reports the pathogenesis of MN and