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目的:探讨病理T1(p T1)期的非小细胞肺癌(NSCLC)淋巴结转移的相关因素。方法:对我院胸外科1997年1月~2013年12月术后病理证实为p T1期且直径≤3cm的NSCLC患者进行回顾性分析。所有统计分析均采用SAS 9.13软件。结果:共入组p T1-NSCLC患者165例,其中男88例、女77例。平均年龄59岁(26~80岁)。发生N1淋巴结转移的比率为19.4%;发生N2淋巴结转移的比率为13.9%;发生N1+N2淋巴结转移的比率为24.2%。单因素分析显示临床N(c N)分期、临床(c)分期及分化程度与N1、N2、N1+N2淋巴结转移有相关性(P<0.01);临床T(c T)分期、病理类型及p T大小与N2淋巴结转移具有相关性(P<0.05)。多因素分析显示仅c N分期与N1、N2、N1+N2淋巴结转移存在相关性(P<0.01)。结论:对于直径≤3cm的NSCLC而言,c N分期与纵隔及肺门、肺内淋巴结转移存在密切关系。肿瘤的病理类型、大小及分化程度与纵隔淋巴结及肺门、肺内淋巴结转移没有相关性。
Objective: To investigate the related factors of pathological T1 (p T1) non-small cell lung cancer (NSCLC) lymph node metastasis. Methods: A retrospective analysis was performed on patients with NSCLC whose pathology was confirmed as p T1 and whose diameter was less than or equal to 3 cm in our hospital from January 1997 to December 2013. All statistical analysis using SAS 9.13 software. Results: A total of 165 patients with p T1-NSCLC were enrolled, including 88 males and 77 females. The average age of 59 years old (26 to 80 years old). The incidence of N1 lymph node metastasis was 19.4%; the incidence of N2 lymph node metastasis was 13.9%; the incidence of N1 + N2 lymph node metastasis was 24.2%. Univariate analysis showed that clinical N (c N) staging, clinical stage (c) and degree of differentiation were correlated with lymph node metastasis of N1, N2 and N1 + N2 (P <0.01) There was a correlation between pT size and N2 lymph node metastasis (P <0.05). Multivariate analysis showed that only cN stage correlated with lymph node metastasis of N1, N2 and N1 + N2 (P <0.01). Conclusion: For NSCLC ≤3cm in diameter, cN stage is closely related to mediastinal, hilar and lymph node metastasis. Tumor pathological type, size and differentiation degree and mediastinal lymph nodes and hilar and lung lymph node metastasis is not related.