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甲基氮杂杯[4]吡啶(MACP-4)是具有独特构象和空腔结构的大环主体分子在客体存在的情况下,它可以通过桥连氮原子的自调节作用而调节整个分子的空腔及构象,以实现对客体最大程度的识别作用.MACP-4对Zn2+具有选择性识别,无论是在固相还是溶液中,它都可以和Zn2+形成稳定的复合物(Zn(II)-MACP-4),结合常数可达5.97(logKs).本文以Zn(Ⅱ)-MACP-4为主体,研究了其与17种氨基酸以及具有不同几何形状的阴离子的识别行为,结果Zn(Ⅱ)-MACP-4对17种氨基酸均具有不同程度的识别,结合常数最高可达3.97(logKs),Zn(Ⅱ)-MACP-4对阴离子的识别具有选择性,其中对PF6-的识别作用最强,结合常数可达3.9(logKs).
Methyl aza-calix [4] pyridine (MACP-4) is a macrocyclic host molecule with unique conformation and cavity structure. In the presence of guest, it can regulate the entire molecule by bridging the self-regulatory effect of nitrogen atom Cavities and conformations to achieve maximum recognition of guest.MACP-4 has a selective recognition of Zn2 +, and it can form a stable complex with Zn2 + in both solid phase and solution (Zn (II) MACP-4), the binding constant can reach 5.97 (log Ks) .In this paper, the recognition behavior of Zn (Ⅱ) -MACP-4 with 17 amino acids and different anions with different geometries was studied. -MACP-4 has different degrees of recognition for 17 kinds of amino acids with a binding constant of up to 3.97 (log Ks). Zn (Ⅱ) -MACP-4 is selective for the recognition of anions, of which PF6- , Binding constants up to 3.9 (logKs).