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目的:探讨转移抑制基因nm23与膀胱移行细胞癌转移之间的关系。方法：应用Northernblot技术分析12例膀胱移行细胞癌和6例肉眼未见异常的癌旁膀胱粘膜nm23-H1和nm23-H2基因的表达。结果：膀胱移行细胞癌组nm23-H1mRNA表达水平较癌旁膀胱粘膜组显著升高，有盆腔淋巴结转移的膀胱程行细胞癌组的nm23-H1mRNA表达显著高于无盆腔淋巴结转移组（P＜0．05），而nm23-H2mRNA在各组间的表达无显著性差异。结论：nm23基因在膀胱移行细胞癌的转移调节中起重要作用。
Objective: To investigate the relationship between metastasis suppressor gene nm23 and transitional cell carcinoma of the bladder. Methods: Northern blot was used to analyze the expression of nm23-H1 and nm23-H2 genes in 12 cases of bladder transitional cell carcinoma and 6 cases of non-cancerous para-cancerous bladder mucosa. Results: The expression of nm23-H1mRNA in bladder transitional cell carcinoma was significantly higher than that in para-cancerous bladder mucosa, while the expression of nm23-H1mRNA in bladder transitional cell carcinoma with pelvic lymph node metastasis was significantly higher than that without pelvic lymph node metastasis (P <0 .05), while the expression of nm23-H2mRNA in each group had no significant difference. Conclusion: The nm23 gene plays an important role in the metastasis of bladder transitional cell carcinoma.