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为了寻求一种适宜的石棉表面改性剂，利用体外细胞培养技术，通过测定培养液中亚硝酸根（ＮＯ－２）含量，观察了茫崖产温石棉对豚鼠肺泡巨噬细胞（ＡＭ）产生一氧化氮（ＮＯ）的诱导作用以及混合稀土、亚硒酸钠、柠檬酸铝对石棉诱发ＡＭ产生ＮＯ的影响。结果显示，温石棉纤维可使培养液中ＮＯ－２浓度升高，并呈明显的剂量反应关系；混合稀土、亚硒酸钠、柠檬酸铝均可抑制石棉诱发ＡＭ产生ＮＯ，而且随上述化合物浓度的升高，抑制作用增强。提示用混合稀土和亚硒酸钠拮抗石棉的致病作用有实际应用的可能。
In order to find a suitable asbestos surface modifier, the production of alveolar macrophages (AM) in guinea pigs was observed by measuring the content of nitrite (NO-2) in culture broth by in vitro cell culture technique. Nitric oxide (NO) induction and the effects of mixed rare earths, sodium selenite and aluminum citrate on NO produced by asbestos-induced AM. The results showed that chrysotile fiber could increase the concentration of NO-2 in the culture medium and showed a dose-response relationship. Mixed rare earth, sodium selenite and aluminum citrate could inhibit asbestos-induced AM to produce NO, and with the above compound Increased concentration, inhibition enhanced. Prompt mixed rare earth and sodium selenite antagonistic pathogenic role of asbestos has practical applications.