论文部分内容阅读
目的：探讨双相障碍Ⅰ型患者血清S100 B蛋白水平与正常人群的差异及与认知功能的相关性。方法选取双相障碍Ⅰ型和对照组各50例，采用酶联免疫（ ELISA ）方法检测两组血清S100 B蛋白浓度，比较其在两组间的差异性，入组对象均通过威斯康星分类（ WCST ）卡片进行认知功能的评估。结果①双相障碍Ⅰ型患者血清S100B水平高于对照组（P＝0.036）。②双相障碍Ⅰ型患者较正常对照组存在明显的认知功能损害（ P均＜0.05），血清S100 B浓度与WCST中的总错误数、持续错误数呈正相关（ P＝0.031；P＝0.006），与正确数、完成分类数呈负相关（ P＝0.045；P＝0.013）。结论双相障碍Ⅰ型患者S100 B蛋白水平与认知功能损害有关。“,”Objective To investigate the correlation of serum S 100 B protein level with cogni-tive function in patients with bipolar disorder type I .Methods Fifty bipolar disorder type I patients were collected and 50 normal persons were as control , the serum S100B protein con-centration was detected by enzyme linked immunoassay (ELISA), the difference in the serum S100 B protein concentration between the two groups was compared , cognitive function was as-sessmentbyWisconsinCardSortingTest(WCST)card.Results ①Thelevelofserum S100 B in patients with bipolar disorder type I was higher than that in control group ( P =0.036 ) .②In patients with bipolar disorder type I , there were significant cognitive impairment ( P<0.05 ) , and serum S100 B concentration was positively correlated with the total number of errors in WCST ( P=0.031;P=0.006 ) , and was negative correlated with the correct number and the number of complete categories ( P=0.045;P=0.013 ) .Conclusion Serum S100 B protein level in patients with bipolar disorder type I is associated with cognitive impairment .