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目的 :考察新生儿期服用黄连或含黄连复方对新生儿有何不良影响。方法 :回顾性调查福建省邵武地区2 0 1例 1978年至 1995年出生的小儿 ,5 1例新生儿期未服用黄连或含黄连方剂作为对照 ,另 15 0例曾在新生儿期服用黄连或含黄连方剂。结果 :全部病例没有 1例发现核黄疸或可疑为核黄疸后遗症。对比服或未服黄连或含黄连方剂小儿的新生儿黄疸发病率、发现早晚、黄疸持续时间 ,两者并没有显著的不同 ;同期血液检验 :血胆红素、红细胞、血色素含量也不存在显著差异 ,没有发现黄连促进新生儿溶血的证据。结论 :调查结果不支持治疗量的黄连对新生儿有毒可以诱发核黄疸的观点。
Purpose : To examine the adverse effects of taking Coptis or containing Coptis on newborns during the neonatal period. METHODS: A retrospective survey of 201 infants born in 1978 to 1995 in the Shaowu area of Fujian Province, 51 infants who had not taken Coptis or Huanglian Recipe as a control during the neonatal period, and 150 infants who had taken coptis during the neonatal period. With Huanglian prescription. RESULTS: None of the cases were found to have nuclear jaundice or suspected sequelae of kernicterus. There was no significant difference in the incidence of neonatal jaundice, the presence of morning and night, and the duration of jaundice in children taking or not taking berberine or in those with jaundice, and there was no significant difference between the two groups in terms of the blood test: blood bilirubin, red blood cells, and hemoglobin levels were not significantly different. Differences, no evidence of hemolysis in newborns was found. Conclusion : The findings do not support the view that treatment of Coptis toxic to neonates can induce nuclear jaundice.