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目的:评价重组人干扰素α-2b阴道泡腾胶囊对宫颈人乳头瘤病毒(HPV)感染患者的临床疗效。方法:选取2015年1月—2016年1月间收治的宫颈HPV感染患者114例,按照随机数字表法将其分为观察组和对照组,每组57例;观察组患者给予重组人干扰素α-2b阴道泡腾胶囊治疗,对照组患者给予复方沙棘籽油栓治疗,比较两组患者治疗1疗程、2疗程和3疗程后总有效率。结果:治疗1疗程后,观察组患者HPV阴转率和宫颈病变治疗的有效率分别为29.82%和40.35%高于对照组为0.00%和0.00%(P<0.05);治疗2疗程后,观察组患者HPV阴转率和宫颈病变治疗的有效率分别为43.86%和52.63%高于对照组为7.02%和10.53%(P<0.05);治疗3疗程后,观察组患者HPV阴转率和宫颈病变治疗的有效率分别为84.21%和87.72%高于对照组为15.79%和17.54%(P<0.05)。结论:重组人干扰素α-2b阴道泡腾胶囊用于治疗宫颈HPV感染患者的临床疗效优于复方沙棘籽油栓的疗效,能提高HPV阴转率和宫颈疾病的有效率。
Objective: To evaluate the clinical efficacy of recombinant human interferon α-2b vaginal effervescent capsules in patients with cervical papillomavirus (HPV) infection. Methods: One hundred and fourteen cases of cervical HPV infection were selected from January 2015 to January 2016, and divided into observation group and control group according to the random number table method, 57 cases in each group. The patients in observation group were given recombinant human interferon α-2b vaginal effervescent capsules treatment, the control group of patients given compound seabuckthorn seed oil suppository treatment, compared two groups of patients treated 1 course of treatment, 2 courses and 3 courses of total efficiency. Results: After 1 course of treatment, the effective rate of HPV negative conversion rate and cervical lesion in the observation group were 29.82% and 40.35% respectively higher than that in the control group (P <0.05); after 2 courses of treatment, The effective rates of HPV negative conversion rate and cervical lesions treatment were 43.86% and 52.63% respectively in the control group and 7.02% and 10.53% in the control group (P <0.05). After 3 courses of treatment, the HPV negative conversion rate and cervix The effective rate of lesion treatment was 84.21% and 87.72% respectively, which was 15.79% and 17.54% higher than that of the control group (P <0.05). Conclusion: The clinical efficacy of recombinant human interferon α-2b vaginal effervescent capsules in the treatment of patients with cervical HPV infection is superior to that of compound sea buckthorn seed oil suppositories, and can improve the efficiency of HPV negative conversion rate and cervical disease.