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Nefiracetam属于γ-氨酪酸的环状衍生物,它的化学名为N-(2,6-二甲苯基)·2-(2-氧代-1-吡咯烷基)-乙酰胺。动物试验结果证明本品有抗遗忘和抗低氧作用,能够提高认知能力。临床前研究结果表明本品在体内吸收良好,能迅速而广泛地分布到各个组织,80%以上药物在24小时内经尿排泄。本文报道本品在健康人体内的药动学。受试者为42例男性日本人,年龄26～56岁,参试前均通过常规体检,前2周内未接受过任何药物,试验期内不得饮酒。试验将受试者随机分为8组,其中1组在禁食过夜后口服本品100mg,其它7组在进常规早餐后的30分钟内分别口服不同剂量的本品,
Nefiracetam belongs to the cyclic derivative of γ-aminobutyric acid and its chemical name is N- (2,6-dimethylphenyl) 2- (2-oxo-1-pyrrolidinyl) -acetamide. Animal test results show that the product has anti-forgetting and anti-hypoxia, can improve cognitive ability. Preclinical studies show that this product is well absorbed in the body and can be quickly and widely distributed to various tissues, and over 80% of the drugs are excreted through the urine within 24 hours. This article reports the pharmacokinetics of this product in healthy humans. Subjects 42 male Japanese, aged 26 to 56 years old, both before passing the routine physical examination, no medication within the first 2 weeks, during the trial shall not be drinking. Test subjects were randomly divided into 8 groups, including a group of fasting overnight oral administration of this product 100mg, the other 7 groups in the regular breakfast within 30 minutes after oral administration of different doses of this product,