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雌酮可防治绝经期后妇女的骨质疏松症。然而,治疗剂量尚不明确。为此,作者在2年内对患者应用不同剂量的雌酮硫酸盐及辅加碳酸钙进行周期性治疗,以观察其不同的疗效。对象和方法研究对象为120例绝经期后的妇女,研究地点为多个医疗中心,采用双盲法研究。雌酮的剂量分别为0.3mg、0.625mg或1.25mg。观察指标是脊椎骨小梁的密度,分析其疗效,并与安慰剂组进行了比较。结果安慰剂组和0.3mg雌酮硫酸盐治疗组的患者出现骨密度减低,前者减低3.6％,后者减低5.1％;而0.625mg和1.25
Estrone prevents and treats postmenopausal women’s osteoporosis. However, the therapeutic dose is not yet known. To this end, the author in two years to patients with different doses of estrone sulfate and calcium supplementation for cyclical treatment to observe its different effects. Subjects and Methods The study population was 120 postmenopausal women with multiple medical centers and a double-blind study. Estrone doses were 0.3 mg, 0.625 mg or 1.25 mg, respectively. The observation index is the density of the trabecular bone of the spine, its efficacy is analyzed, and compared with the placebo group. Results Patients in the placebo group and the estrogen sulphate 0.3 mg group experienced a decrease in BMD of 3.6% for the former and 5.1% for the latter, whereas 0.625 mg for the placebo and 1.25