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目的探讨急性淋巴细胞白血病（ＡＬＬ）患者化疗后发生肿瘤溶解综合征（ＴＬＳ）的临床特征及预后。方法对４例化疗早期发生ＴＬＳ的ＡＬＬ患者进行各项实验生化指标的分析。结果ＴＬＳ患者表现为高尿酸血症、高血钾、高血磷、低血钙，并有不同程度的肾功能损伤，其中１例发生了急性肾功能不全。用别嘌呤醇及静脉碱化利尿后，３例短期内血液生化指标恢复正常。１例死于急性肾功能不全。结论早期诊断并及时给予别嘌呤醇及静脉碱化利尿是治疗ＴＬＳ的关键。
Objective To investigate the clinical features and prognosis of tumor lysis syndrome (TLS) after chemotherapy in patients with acute lymphoblastic leukemia (ALL). Methods The biochemical indicators of 4 cases of ALL with TLS in early stage of chemotherapy were analyzed. Results The patients with TLS showed hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and renal function impairment in varying degrees. Acute renal insufficiency occurred in 1 patient. After allopurinolation with allopurinol and iv, the blood biochemical parameters returned to normal in 3 cases in a short period of time. One patient died of acute renal insufficiency. Conclusion Early diagnosis and timely administration of allopurinol and intravenous alkalization and diuresis are the keys to the treatment of TLS.