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糖尿病控制指标有血糖和 HbA_1,最近一种比HbA_1转运快的糖基化蛋白——血清果糖胺测定作为糖尿病血糖控制的指标已广泛应用。果糖胺能反映1～2周前血糖水平。在研究探讨其作为糖尿病孕妇血糖控制较佳指标的可能性。病人和方法 60例糖尿病孕妇,6例在妊娠期中发病,54例为妊娠前已获确诊。全部接受胰岛素治疗。胰岛素依赖型糖尿病(IDDM)18例,非胰岛素依赖型糖尿病(NIDDM)42例。分娩时 IDDM 平均年龄29.4±4.6岁,NIDDM 平均年龄为30.1±3.9岁。至分娩平均病程分别为9.3±6.4和4.3±4.2年。以107名正常孕妇、183例糖尿病非孕妇和42名健康非孕妇作为对照,观察其不同孕期空腹时血清果糖胺浓度的变化。果糖胺测定法:血清分离后,于-20℃保存,于2周内用 Johnson 法测定。
Diabetes control indicators of blood glucose and HbA_1, a more recent HbA_1 transport of glycosylated protein - serum fructosamine assay as an indicator of glycemic control of diabetes has been widely used. Fructosamine can reflect the level of blood glucose 1 to 2 weeks ago. In the study to explore its potential as a better indicator of glycemic control in pregnant women with diabetes. Sixty patients with diabetes mellitus and gestational diabetes were diagnosed during pregnancy, and 54 patients were diagnosed before pregnancy. All accept insulin treatment. 18 cases of insulin-dependent diabetes mellitus (IDDM) and 42 cases of non-insulin-dependent diabetes mellitus (NIDDM). The average age of IDDM at delivery was 29.4 ± 4.6 years and that of NIDDM was 30.1 ± 3.9 years. The average course of delivery to 9.3 ± 6.4 and 4.3 ± 4.2 years respectively. A total of 107 normal pregnant women, 183 non-pregnant women with diabetes and 42 healthy non-pregnant women were used as controls to observe the changes of serum fructosamine concentration during different fasting periods. Fructosamine Assay: After sera were separated and stored at -20 ° C, the titration was performed by Johnson method within 2 weeks.