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目的探讨乳腺癌前哨淋巴结活检(SLNB)中吲哚菁绿(ICG)联合纳米炭悬浊液的应用价值。方法将110例腋窝淋巴结阴性的早期乳腺癌患者,随机分成两组,分别采用注射用ICG联合纳米炭悬浊液(联合组,57例)和单用纳米炭悬浊液(纳米炭组,53例)为示踪剂行SLNB。SLNB后随即行腋窝淋巴结清扫。结果联合组中55例可见荧光所示淋巴管道,荧光显像率96.49%(55/57),前哨淋巴结检出率98.25%(56/57),准确率96.43%(54/56),假阴性率6.67%(2/30),灵敏度93.33%(28/30);纳米炭组前哨淋巴结检出率94.34%(50/53),准确率96.00%(48/50),假阴性率8.33%(2/24),灵敏度91.67%(22/24)。联合组共检出前哨淋巴结309枚,纳米炭组共检出前哨淋巴结218枚,两组前哨淋巴结平均检出枚数比较差异有统计学意义(P<0.05);而两组检出率、准确率、假阴性率和灵敏度这4个评价指标比较,差异均无统计学意义。结论 ICG与纳米炭悬浊液联合应用相比单用纳米炭悬浊液可提高前哨淋巴结检出数量,减少漏诊概率。
Objective To investigate the value of indocyanine green (ICG) combined with nanocarbon suspension in sentinel lymph node biopsy (SLNB) in breast cancer. Methods One hundred and ten patients with early stage breast cancer with negative axillary lymph node were randomly divided into two groups: ICG injection combined with nanocarbon suspension (combination group, 57 cases) and nanocarbon suspension alone (nanocarbon group, 53 Example) SLNB for tracer. Axillary lymph node dissection immediately after SLNB. Results The lymphatic vessels were visible in 55 cases in the combined group. The fluorescence imaging rate was 96.49% (55/57), the sentinel lymph node detection rate was 98.25% (56/57), the accuracy rate was 96.43% (54/56), the false negative The positive rate was 6.67% (2/30) and the sensitivity was 93.33% (28/30). The detection rate of sentinel lymph node was 94.34% (50/53), the accuracy rate was 96.00% (48/50) and the false negative rate was 8.33% 2/24), sensitivity 91.67% (22/24). A total of 309 sentinel lymph nodes were detected in the combined group and 218 sentinel lymph nodes were detected in the nanocarbon group. The mean number of sentinel lymph nodes was significantly different between the two groups (P <0.05), while the detection rate and accuracy , False negative rate and sensitivity of the four evaluation indicators, the difference was not statistically significant. Conclusion ICG and nanocarbon suspension combined application of nanocarbon suspension alone can increase the number of sentinel lymph nodes and reduce the probability of missed diagnosis.