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目的 分析15年间单中心颅内脑膜瘤患者临床及病理特征和治疗效果。方法 回顾性分析845例手术治疗的脑膜瘤患者的临床病理及预后资料,应用Kaplan-Meier法、log-rank检验和Cox回归模型对性别、年龄、WHO病理级别、术前KPS评分等临床病理特征进行单因素和多因素生存分析。结果 845例脑膜瘤患者中男235例,女610例,年龄(49.96±12.17)岁,总随访时间1～240个月,中位随访时间5.00个月。57例术后复发,其中WHOⅠ级脑膜瘤复发36例(4.9%,36/732),WHOⅡ级脑膜瘤复发14例(17.1%,14/82),WHOⅢ级脑膜瘤复发7例(7/31)。WHO病理分级高和男性是脑膜瘤复发高危因素。结论 WHOⅡ和Ⅲ级脑膜瘤手术后易复发,对于高危患者需要采取积极辅助治疗并严密随访。
Objective To analyze the clinical and pathological features and therapeutic effects of single-center intracranial meningioma in 15 years. Methods The clinicopathological and prognostic data of 845 surgically treated meningioma patients were retrospectively analyzed. The clinicopathological features such as gender, age, WHO pathological grade, and preoperative KPS scores were evaluated by Kaplan-Meier method, log-rank test and Cox regression model. Perform univariate and multivariate survival analysis. Results Among 845 cases of meningiomas, 235 were male and 610 were female. The age was (49.96±12.17) years. The total follow-up time was 1 to 240 months. The median follow-up time was 5.00 months. Fifty-seven cases relapsed, including 36 cases with WHOI meningiomas recurrence (4.9%, 36/732), 14 cases with WHO II meningiomas recurrence (17.1%, 14/82), and 7 cases with WHO III meningiomas recurrence (7/31). ). The high pathological grade of WHO and men are high risk factors for meningioma recurrence. Conclusions WHOII and III meningioma are easy to relapse after surgery. For high-risk patients, active adjuvant therapy is needed and followed up closely.