各种原因的心肌疾病和导致心脏负担过重的病因均可直接或间接引起心肌细胞变性坏死,收缩与舒张功能降低,最终导致心力衰竭。而既往的研究表明心肌细胞在出生后立即停止分裂,心肌没有成肌细胞,对于有丝分裂信号作出的反应是肥大而非增殖,意味着心肌细胞一旦出现坏死变性后 Various causes of myocardial disease and lead to the cause of cardiac overweight can cause direct or indirect myocardial cell degeneration and necrosis, reduced systolic and diastolic function, and ultimately lead to heart failure. Previous studies have shown that cardiomyocytes stop dividing immediately after birth, that myocytes do not have myoblasts, and that response to mitotic signals is hypertrophic rather than proliferative, meaning that once cardiomyocytes undergo necrotic degeneration