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目的 研究高血压 (EH)患者脉压 (PP)与大动脉扩张性、内皮功能的关系。方法 选择 1 0 9例EH患者 ,其中男性56例 ,女性 53例 ,平均年龄 60 8± 6 2岁。将所有病例按PP值分成四组 ,应用B超声对颈动脉、肱动脉进行扫查 ,在静息、反应性充血时和舌下含服硝酸甘油后对肱动脉内径进行检测。结果 颈总动脉舒张期直径 (DD)随PP增大而增加 ,收缩期与舒张期直径之差 (DS D)及DS D/DD却随PP增大而减小 ,PP与IMT呈正相关关系 ,其相关性强于收缩压 (SBP)、舒张压 (DBP)、平均压 (MAP)。加压充血后 ,肱动脉管径平均扩增 (Flow MD) 3 %～ 1 3 % ,随PP增大 ,Flow MD逐渐减小 ,各组差异有显著性 (P <0 0 5)。结论 PP增大与高血压患者大动脉扩张性降低、管壁增厚 ,内皮功能受损关系密切
Objective To study the relationship between pulse pressure (PP) and aortic dilatation and endothelial function in patients with hypertension (EH). Methods One hundred and nine patients with EH were selected, including 56 males and 53 females, with an average age of 60 8 ± 6 2 years. All cases were divided into four groups according to the PP value. The carotid artery and brachial artery were scanned with B ultrasound, and the brachial artery diameter was measured after resting, reactive hyperemia and sublingual nitroglycerin. Results The diastolic diameter (DD) of common carotid arteries increased with the increase of PP. The difference of DS D and DS D / DD between systolic and diastolic diameters decreased with the increase of PP. PP and IMT had a positive correlation, The correlation was stronger than SBP, DBP and MAP. After pressure hyperemia, the average brachial artery diameter (Flow MD) was increased from 3% to 13%. With increasing PP, Flow MD gradually decreased and the difference was significant (P <0.05). Conclusions The increase of PP is closely related to the decrease of arterial expansion, wall thickening and impaired endothelial function in hypertensive patients