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先天性心脏病(congenital heart disease,CHD)属于多基因遗传病,遗传因素在CHD发病中起重要作用,遗传度为55%-65%[1]。心脏胚胎发育涉及不同时间、不同空间若干基因的先后表达以及这些基因间复杂而精确的相互作用。心脏发育过程中有大量转录
Congenital heart disease (CHD) belongs to polygenic disease, genetic factors play an important role in the pathogenesis of CHD, the heritability of 55% -65% [1]. Cardiac embryonic development involves the sequential expression of several genes at different times and in different spaces and the complex and precise interactions between these genes. There is a lot of transcription during heart development