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TBX20是T-box转录因子家族的一员，在心脏发育过程中发挥重要作用，在帮助维持成年人正常心功能方面也有一定作用。TBX20在心脏发育过程中既可作为转录激活因子也可作为转录抑制因子，并表现出复杂的时空调控作用。TBX20是先天性心脏病(congenital heart disease，CHD)的重要候选转录因子，其突变或表达改变都会导致CHD的发生。该文综述了TBX20在心脏发育中参与的信号通路、TBX20与其他心脏转录因子的相互作用等TBX20在心脏发育领域的最新研究进展。“,”TBX20 gene, a member of the T-box gene family, plays an important role during heart development and is required for maintaining adult heart function.TBX20 can act as both transcriptional activator and transcriptional suppressor during the development of the heart, and shows complex spatiotemporal regulation.TBX20 is an important candidate transcription factor for the pathogenesis of congenital heart disease(CHD), and its mutation or expression change can lead to the occurrence of CHD.In this paper, the latest research progress of TBX20 gene in the field of heart development is reviewed from the relationship between TBX20 and CHD, the signaling pathway involved in heart development and its interactions with other cardiac transcription factors.