论文部分内容阅读
目的:分析乌司他丁联合连续肾脏替代疗法(CRRT)对严重脓毒症患者炎症因子水平及器官功能的影响。方法:选取佛山市第二人民医院重症医学科近2年收治的严重脓毒症患者94例,按抽签顺序分为两组,各47例。对照组实施常规治疗,观察组在对照组基础上采用乌司他丁联合CRRT治疗,比较两组患者治疗前后炎症因子水平及生化指标变化情况。结果:治疗后,观察组肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平较对照组明显降低,差异具有统计学意义(P<0.05);观察组丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酐(Cr)、尿素氮(BUN)较对照组明显降低,氧合指数(PaO_2/FiO_2)明显升高,差异具有统计学意义(P<0.05)。结论:对严重脓毒症患者在常规治疗的基础上实施乌司他丁联合CRRT治疗效果较为显著,可有效降低炎症因子水平,促进器官功能恢复。
Objective: To analyze the effects of ulinastatin combined with continuous renal replacement therapy (CRRT) on inflammatory cytokines and organ function in patients with severe sepsis. Methods: Ninety - four patients with severe sepsis admitted to the Second People ’s Hospital of Foshan City during the past two years were divided into two groups (n = 47). The control group was given conventional treatment. The observation group was treated with ulinastatin combined with CRRT on the basis of the control group. The levels of inflammatory cytokines and biochemical indexes in both groups were compared before and after treatment. Results: The levels of tumor necrosis factor-α (TNF-α), procalcitonin (PCT) and hs-CRP in the observation group were significantly lower than those in the control group after treatment (P <0.05). ALT, AST, LDH, CK, Cr and BUN in the observation group were significantly lower than those in the control group The coincidence index (PaO 2 / FiO 2) increased significantly, the difference was statistically significant (P <0.05). Conclusion: The treatment of patients with severe sepsis based on routine treatment of ulinastatin combined with CRRT treatment is more effective, which can effectively reduce the level of inflammatory cytokines and promote the recovery of organ function.