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目的:探讨中药穴位注射联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎的疗效。方法:使用柴胡注射液、黄芪注射液、丹参注射液分别注射曲池、足三里、三阴交穴位,联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎62例,随机分组后,观察穴位组与对照组两组的HBV-DNA阴转率、肝功能复常率以及Zung抑郁量表评分。结果:治疗后1周、24周、48周的穴位组SDS评分均明显比对照组低,且在治疗的第1周两组评分分别是(44.1±6.9)和(63.6±3.9),P<0.05,存在显著性差异;穴位组的肝功复常率及DNA阴转率高于单纯使用干扰素治疗的对照组,但差异无统计学意义。结论:中药穴位注射联合聚乙二醇干扰素a-2a治疗慢性乙型肝炎,可减少干扰素的不良反应,且疗效优于对照组。
Objective: To investigate the curative effect of acupoint injection of Chinese medicine combined with pegylated interferon alpha 2a on chronic hepatitis B patients. Methods: Bupleurum injection, Astragalus injection and Salvia miltiorrhiza injection were respectively injected into Quchi, Zusanli and Sanyinjiao points, combined with peginterferon alfa-2a to treat 62 cases of chronic hepatitis B, randomly divided into groups and observed the acupoints Group HBV DNA negative rate and control group, normal rate of liver function and Zung depression scale score. Results: SDS scores of acupoint group were significantly lower than those of the control group at 1 week, 24 weeks and 48 weeks after treatment, and the scores of the two groups were (44.1 ± 6.9) and (63.6 ± 3.9), respectively, in the first week of treatment (P < 0.05, there was a significant difference; point group of liver function recovery rate and DNA negative conversion rate higher than the simple use of interferon treatment control group, but the difference was not statistically significant. Conclusion: Chinese medicine acupoint injection combined with peginterferon alfa-2a in the treatment of chronic hepatitis B can reduce the adverse reaction of interferon, and the curative effect is better than the control group.