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为探讨角膜移植排斥反应植片中的免疫组织细胞的分布，揭示排斥反应的机理。应用免组织化学技术研究了３０例人角膜中朗格罕氏细胞（ＬＣ）和组织相容性抗原（ＨＬＡ－ＤＲ）的表达。其结果表明：在角膜中央直径７ｍｍ范围内，正常人角膜全层未见ＨＬＡ－ＤＲ抗原阳性树枝状细胞；病变角膜中，ＨＬＡ－ＤＲ抗原阳性树枝状细胞主要集中分布于中央区角膜上皮及浅实质层中。本结果说明：朗格罕氏细胞和组织相容性抗原在角膜移植排斥反应中起着重要作用，减少其存在可达到预防和降低排斥反应发生的目的。
To investigate the distribution of immune cells in corneal transplant rejection and to reveal the mechanism of rejection. The expression of Langerhans cells (LC) and histocompatibility antigens (HLA-DR) in 30 human corneas was studied by immunohistochemistry. The results showed that there was no HLA-DR antigen-positive dendritic cells in the normal corneal whole cornea in the 7 mm diameter central cornea. In the diseased cornea, HLA-DR antigen-positive dendritic cells were mainly concentrated in the central corneal epithelium and shallow In the real world. The results show that: Langerhans cells and histocompatibility antigens play an important role in the rejection of corneal allografts, reducing their presence can achieve the purpose of preventing and reducing the occurrence of rejection.