Whipple病(Whipple’s disease,惠普尔病,又称肠源性脂肪代谢障碍)于1907年首次由Whipple报道,是一种罕见的以腹泻和吸收障碍等多种胃肠道症状为特征的慢性多系统疾病,部分患者仅表现为关节、心脏或神经系统症状。好发于中老年男性白种人,但女性和所有种族均易感。近年来,随着聚合酶链式反应(PCR)技术在临床的广泛应用,本病诊断报告日渐增多。 Whipple’s disease (Whipple’s disease, also known as gut-derived lipodystrophy), first reported by Whipple in 1907, is a rare chronic multi-system characterized by multiple gastrointestinal symptoms, such as diarrhea and malabsorption Disease, some patients only showed the joint, heart or nervous system symptoms. Occur in middle-aged and older men, white, but women and all races are susceptible. In recent years, with the polymerase chain reaction (PCR) technology widely used in clinical, the diagnosis of this disease is increasing.