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人类免疫缺陷病毒1型(HIV-1)感染者自身的持续免疫活化程度是决定疾病进展的关键。过度免疫活化导致机体免疫系统功能亢进,多种免疫细胞功能改变。髓源性抑制细胞(MDSC)是具有免疫抑制作用的细胞,参与机体免疫调节。在HIV-1感染者中,MDSC显著增多且与CD4+T细胞绝对数等疾病进展指标有关。随着高效抗逆转录病毒治疗的实施,MDSC也发生相应变化。疫苗诱导的MDSC对保护性细胞免疫应答有抑制作用,提示阻止MDSC的诱导可能提高HIV疫苗的有效性。因此,了解MDSC在HIV-1感染者中功能的改变有利于进一步探究HIV-1感染者免疫活化状态的成因,为HIV-1的治疗以及疫苗的研制提供新思路。
The extent of persistent immune activation in individuals infected with human immunodeficiency virus type 1 (HIV-1) is key to determining disease progression. Excessive immune activation leads to the body’s immune system hyperthyroidism, a variety of immune cell function changes. Myeloid suppressor cells (MDSCs) are immunosuppressive cells involved in the immune regulation of the body. Among HIV-1-infected persons, MDSCs are significantly increased and correlated with disease progression indicators such as the absolute number of CD4 + T cells. With the implementation of highly effective antiretroviral therapy, MDSC also changed accordingly. Vaccine-induced MDSCs have an inhibitory effect on protective cellular immune responses, suggesting that blocking the induction of MDSCs may improve the effectiveness of the HIV vaccine. Therefore, to understand the function of MDSC in HIV-1 infected patients is conducive to further explore the causes of immune activation of HIV-1 infection, provide a new idea for the treatment of HIV-1 and vaccine development.