[目的]观察中药枳术汤加味对大鼠肠黏膜屏障通透性的影响。[方法]60只雄性Wistar大鼠,随机分为3组,各20只。对照组,实验前给予0.85%氯化钠0.35 ml;模型对照(模型)组,术前给予0.85%氯化钠0.35 ml;模型治疗(治疗)组,术前给予中药枳术汤0.35 ml;均2次/d灌胃,连续7 d;通过夹闭肠系膜上动脉30 min后重新开放,建立肠道缺血-再灌注(IR)损伤模型;于灌注后1、24 h分别检测各组肠道细菌移位发生率、细菌培养阳性率、外周血浆D-乳酸浓度和二胺氧化酶(DAO)浓度。[结果]IR后1 h和24 h,比较肠道细菌移位阳性率、细菌培养阳性率、血浆D-乳酸和DAO浓度,模型组>对照组(P<0.05),治疗组<模型组(P<0.05)。[结论]中药枳术汤加味能抑制肠道细菌移位,降低肠黏膜的通透性,对肠黏膜屏障有较好的保护作用。 [Objective] To observe the effect of Chinese herbal medicine Zhuzhi decoction on the permeability of rat intestinal mucosal barrier. [Methods] Sixty male Wistar rats were randomly divided into 3 groups with 20 rats each. In the control group, 0.85 ml of sodium chloride 0.85 ml before the experiment, 0.85 ml of 0.85% sodium chloride in the model control group before the operation, and 0.35 ml of the curative treatment (treatment) group before the operation were given. 2 times / d gavage, continuous 7 d; 30 minutes after the upper mesenteric artery was clamped and reopened, intestinal ischemia-reperfusion (IR) injury model was established; Intestinal tract of each group was detected at 1, 24 h after perfusion. Incidence of bacterial translocation, positive rate of bacterial culture, peripheral plasma D-lactic acid concentration, and diamine oxidase (DAO) concentration. [Results] 1 hour and 24 hours after IR, the positive rate of bacterial translocation in the intestine, positive rate of bacterial culture, plasma D-lactic acid and DAO concentration were compared. Model group> control group (P<0.05), treatment group