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目的:研究幽门螺杆菌(Hp)的根除对长期服用非甾体消炎药(NSAID)致消化性溃疡愈合和复发的影响。方法:将71例长期服用NSAID的消化性溃疡患者分为Hp阳性奥美拉唑组26例,Hp阳性奥美拉唑加阿莫西林组24例,Hp阴性奥美拉唑组21例,3组的用药时间均为6周。追踪溃疡愈合者43例,并分为Hp根除组13例,Hp持续阳性组16例,Hp持续阴性组14例。均停用抗溃疡药物,继服用NSAID 6个月后复查。结果:3组溃疡愈合率依次为A组65.4%,B组75.0%,C组71.4%,3组比较差异无显著性(P>0.05)。Hp根除组、Hp持续阳性组、Hp持续阴性组累计溃疡复发率分别为30.8%,43.8%,28.6%,3组比较差异无显著性(P>0.05)。结论:根除Hp不能提高NSAID相关消化性溃疡的愈合率,亦不能降低其复发率。
Objective: To investigate the effect of Helicobacter pylori (Hp) eradication on the healing and recurrence of peptic ulcer induced by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). Methods: Totally 71 NSAID-treated peptic ulcer patients were divided into Hp positive omeprazole group (n = 26), Hp positive omeprazole plus amoxicillin group (n = 24), Hp negative omeprazole group (n = 21) Group medication time are 6 weeks. 43 cases were followed up for ulcer healing, and were divided into Hp eradication group (13 cases), Hp persistent positive group (16 cases) and Hp persistent negative group (14 cases). Anti-ulcer drugs were discontinued, followed by NSAID 6 months after the review. Results: The healing rates of three groups were 65.4% in group A, 75.0% in group B and 71.4% in group C, respectively. There was no significant difference between the three groups (P> 0.05). Hp eradication group, Hp persistent positive group, Hp sustained negative group cumulative ulcer recurrence rates were 30.8%, 43.8%, 28.6%, respectively, the difference was not significant in the three groups (P> 0.05). Conclusion: Eradication of Hp can not improve the healing rate of NSAID-related peptic ulcer, nor can it reduce the recurrence rate.