巨细胞病毒(Cytomegalo Virus,CMV)属疱疹病毒类的一组病毒,分布广泛,人及其他哺乳动物受该组病毒感染很普遍,它们对宿主或组织培养细胞有明显的种属特异性。宿主感染后,可从无症状到严重的先天缺陷或死亡。体内和组织培养中可产生细胞病理作用,有典型的胞浆内及核内包涵体,故称巨细胞病毒。由于先天性感染,器官移植,肿瘤等研究的深入,CMV越来越引起了人们的重视,本文就CMV的致病性与免疫性作一简单叙述。 Cytomegalo Virus (CMV) is a group of viruses belonging to the herpes virus family and is widely distributed. It is common for humans and other mammals to be infected with this group of viruses. They have distinct species-specificities in host or tissue culture cells. Host infection can be asymptomatic to severe birth defects or death. In vivo and tissue culture can produce cytopathic effects, there are typical cytoplasmic and nuclear inclusions, so called cytomegalovirus. Due to the research of congenital infection, organ transplantation and tumor, more and more attention has been paid to CMV. In this paper, the pathogenicity and immunity of CMV are briefly described.