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Buring(1988)曾报道氨基糖苷类的治疗指数很窄。当前推荐的庆大霉素、妥布拉霉素和乙基西索米星的血浓度高峰至少为6mg/L(30分钟输注后30分钟测定),并且谷浓度小于2mg/L。对丁胺卡那霉素(AMK)来说相应的血峰浓度≥20mg/L和谷浓度
Buring (1988) reported that the therapeutic index of aminoglycosides is very narrow. Currently recommended gentamicin, tobramycin and ethylsioxetine have peak blood concentrations of at least 6 mg / L (measured 30 minutes after 30 minutes of infusion) and a trough concentration of less than 2 mg / L. For amikacin (AMK), the corresponding peak blood concentration was> 20 mg / L and the trough concentration