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gp 160的gp 120部分与人CD4结合,CD4是唯一已明确鉴定的HIV-1,HIV-2和SIV 的高亲和力受体。病毒芽生期间细胞蛋白酶将gp160裂解产生gp120和gp41;gp120作为HIV 外壳糖蛋白的外层以三聚或多聚体形式与gp41非共价键结合。感染细胞培养上清中亦有游离的gp120。结合CD4的活性位于422-437氨基酸之间,417是关键氨基酸。gp120有3个区域与Ig 基因超家族成员同源;261-270氨基酸与HLA-DR、-DP 和-DQ β链142-151氨基酸明显同源;氨基酸415-451与DQ β链15-63略同源;CD4结合区本身与IgV 区的CDR 氨
The gp 120 portion of gp 160 binds to human CD4, the only high-affinity receptor for HIV-1, HIV-2 and SIV that has been specifically identified. Cell proteases cleave gp160 to produce gp120 and gp41 during viral budding; the outer layer of gp120 as HIV coat glycoprotein binds non-covalently to gp41 as a trimeric or multimeric form. Infected cell culture supernatants also have free gp120. The binding activity of CD4 is between 422-437 amino acids and 417 is the key amino acid. Three regions of gp120 are homologous to members of the Ig gene superfamily; 261-270 amino acids are significantly homologous to amino acids 142-151 of HLA-DR, -DP and -DQ β chains; amino acids 415-451 and DQ β chains 15-63 Homology; CDR-binding of the CD4 binding region itself to the IgV region