As one of the areas with numerous lakes on the Tibetan Plateau, the Hoh Xil region plays an extremely important role in the fragile plateau eco-environment. Based on topographic maps in the 1970 s and Landsat TM/ETM+ remote sensing images in the 1990 s and the period from 2000 to 2011, the data of 83 lakes with an area above 10 km2 each were obtained by digitization method and artificial visual interpretation technology, and the causes for lake variations were also analyzed. Some conclusions can be drawn as follows.(1) From the 1970 s to 2011, the lakes in the Hoh Xil region firstly shrank and then expanded. In particular, the area of lakes generally decreased during the 1970s–1990s. Then the lakes expanded from the 1990 s to 2000 and the area was slightly higher than that in the 1970 s. The area of lakes dramatically increased after 2000.(2) From 2000 to 2011, the lakes with different area ranks in the Hoh Xil region showed an overall expansion trend. Meanwhile, some regional differences were also discovered. Most of the lakes expanded and were widely distributed in the northern, central and western parts of the region. Some lakes were merged together or overflowed due to their rapid expansion. A small number of lakes with the trend of area decrease or strong fluctuation were scattered in the central and southern parts of the study area. And their variations were related to their own supply conditions or hydraulic connection with the downstream lakes or rivers.(3) The increase in precipitation was the dominant factor resulting in the expansion of lakes in the Hoh Xil region. The secondary factor was the increase in meltwater from glaciers and frozen soil due to climate warming. As one of the areas with numerous lakes on the Tibetan Plateau, the Hoh Xil region plays an extremely important role in the fragile plateau eco-environment. Based on topographic maps in the 1970 s and Landsat TM / ETM + remote sensing images in the 1990 s and the period from 2000 to 2011, the data of 83 lakes with an area above 10 km2 each were obtained by digitization method and artificial visual interpretation technology, and the causes for lake variations were also analyzed. 1) From the 1970s to 2011, the lakes in the Hoh Xil region first shrank and then expanded. In particular, the area of ​​lakes generally like during the 1970s-1990s. Then the lakes expanded from the 1990 s to 2000 and the area was slightly higher than that in the 1970 s. The area ofkes dramatic increased after 2000. (2) From 2000 to 2011, the lakes with different area ranks in the Hoh Xil region showed an overall expansion trend. Meanwhile, some regional differ Most of the lakes expanded and were widely distributed in the northern, central and western parts of the region. Some lakes were merged together or overflowed due to their rapid expansion. A small number of lakes with the trend of area decrease or strong fluctuation were scattered in the central and southern parts of the study area. And their variations were related to their own supply conditions or hydraulic connection with the downstream lakes or rivers. (3) The increase in precipitation was the dominant factor resulting in the the expansion of lakes in the Hoh Xil region. The secondary factor was the increase in meltwater from glaciers and frozen soil due to climate warming.