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干扰素(IF)能够增强天然杀伤细胞(NK)介导的人外周血淋巴细胞的细胞毒性已得到确认,而IF是否能够增强抗体依赖性细胞介导的细胞毒性(ADCC),结果却不一致。本文报告一种纯净IF制剂可以增强ADCC抗外周血单个核靶细胞的活性。本项研究的目的是试图改进ADCC测定法在检测与输血引起的致敏以及临床骨髓移植排斥有关的抗体的鉴别力。
The effect of interferon (IF) on cytotoxicity of natural killer (NK) -mediated human peripheral blood lymphocytes has been confirmed, but whether IF enhances antibody-dependent cell-mediated cytotoxicity (ADCC) is not consistent. This article reports a pure IF preparation can enhance ADCC anti-peripheral blood mononuclear target cell activity. The aim of this study was to attempt to improve the discriminability of ADCC assays in the detection of antibodies associated with blood transfusion-induced sensitization and clinical bone marrow transplant rejection.