论文部分内容阅读
由于神经细胞质膜上的多种离子通道和受体是神经毒素的天然靶物质,所以神经毒素在这些膜蛋白的生理功能及结构性质研究中已成为十分有用的工具.从各种蛇毒分离的神经毒素分为在突触后选择地阻遏神经肌肉接头传递的α型毒素以及突触前抑制递质释放的β型毒素两类.α-银环蛇神经毒素作为一种突触后毒素在nACh受体的发现、鉴定、分离及结构功能研究中所起的关键性作用是众所周知的,但与此形成对照的是,突触前过程及有关通道、受体的研究鉴定工作却进展有限.缺乏合适的探针是造成这种状况的原因之一.
Since many ion channels and receptors on the plasma membrane of nerve cells are natural targets of neurotoxins, neurotoxins have become a very useful tool in the study of the physiological function and structural properties of these membrane proteins.Nerns isolated from various venom Toxins are classified into alpha-toxins that selectively block the delivery of neuromuscular junctions post-synaptically and beta-type toxins that release presynaptically-mediated neurotransmitters. As a synaptic toxin, The crucial role of the body in the discovery, identification, separation, and structural function studies is well known, but in contrast to this, there is limited progress in the research of presynaptic processes and related channels and receptors, The probe is one of the causes of this condition.