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本文采用抗HTg McAb间接免疫荧光法,对46例病理性甲状腺组织中HTg的分布及特点作了分析。结果发现:弥漫性毒性甲状腺肿的荧光着色最强、分布最广泛,而结节性甲状腺肿、甲状腺滤泡性腺瘤的滤泡上皮细胞浆及胶质的荧光着色相比较弱。亚急性甲状腺炎的滤泡上皮细胞浆及胶质可见荧光着色,慢性甲状腺炎、桥本氏病。淋巴性甲状腺炎均来见明显荧光着色,乳头状甲状腺癌癌细胞浆有不同程度的荧光着色,而髓样癌、未分化癌及转移性癌均无荧光着色。 这些结果指示:HTg免疫组化分析将有助于病理性甲状腺组织的细胞分化度、组织起源等的研究及鉴别诊断。
In this paper, anti-HTg McAb indirect immunofluorescence method was used to analyze the distribution and characteristics of HTg in 46 cases of pathological thyroid tissue. The results showed that diffuse toxic goiter had the strongest and most widely distributed fluorescent staining, whereas nodular goiter and thyroid follicular adenoma had weaker follicular epithelial cell cytoplasm and glial fluorescent staining. Subacute thyroiditis in the follicular epithelial cell cytoplasm and fluorescent staining, chronic thyroiditis, Hashimoto’s disease. Lymphoid thyroiditis all had obvious fluorescent staining. Papillary thyroid cancer cells had different degrees of fluorescent staining, while medullary carcinoma, undifferentiated carcinoma, and metastatic carcinoma had no fluorescent staining. These results indicate that HTg immunohistochemical analysis will contribute to the study and differential diagnosis of pathological thyroid tissue cell differentiation, tissue origin, and the like.