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卤代烃是一类致突变污染物 ,除工厂废水废气中存在外 ,饮用水由于用氯气消毒亦可检出。这是一类无需代谢便可直接使ＤＮＡ碱基烷基化而造成ＤＮＡ损伤的亲电化合物 ,因此对其毒性评价是研究的热点之一。 2 吡啶酮与ＤＮＡ碱基鸟嘌呤及胸腺嘧啶有类似结构 ,是研究ＤＮＡ碱基及
Halogenated hydrocarbons are a group of mutagenic pollutants, in addition to the existence of factory waste water emissions, drinking water as chlorine gas can also be detected. This is a class of electrophilic compounds that directly alkylate DNA without causing DNA damage. Therefore, the evaluation of its toxicity is one of the hot topics. 2 pyridone and DNA base guanine and thymine have similar structures, is to study DNA bases and